Adipotide — Research Overview

Also known as: FTPP, Fat-targeted proapoptotic peptide, Prohibitin-targeted peptide

A chimeric proapoptotic peptide designed to selectively destroy blood vessels supplying white adipose tissue. Adipotide binds PROHIBITIN on fat-associated vasculature then disrupts cell membranes via a proapoptotic GLA domain, starving fat cells of nutrients and inducing adipocyte death. Studied for obesity treatment in primate models.

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