Klotho — Research Overview

Also known as: Alpha-Klotho, KL protein, FGF23 co-receptor

A pleiotropic aging-suppressor protein encoded by the KL gene. Klotho functions as both a membrane co-receptor for FGF23 and as a circulating hormone regulating phosphate metabolism, kidney function, neuroplasticity, and longevity-associated pathways. Declining Klotho levels with age are associated with accelerated aging, cognitive decline, and cardiovascular disease.

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