PNC-27 — Research Overview
Also known as: PNC27, p53-derived anticancer peptide
A p53-derived chimeric peptide that selectively induces apoptosis in cancer cells while leaving normal cells unaffected. PNC-27 contains the MDM2-binding domain of p53 fused to a membrane-penetrating leader sequence, allowing it to insert into cancer cell membranes and trigger selective pore formation and necrosis in transformed cells.
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