Fisetin is a plant-derived flavonol found in strawberries, apples, onions and other foods. It is investigated for cellular stress responses, inflammation and the biology of senescent cells. The page distinguishes laboratory and animal findings from the comparatively limited human evidence, rather than describing an established anti-aging treatment.
What Is Fisetin?
Fisetin is a plant-derived flavonol, a subgroup of polyphenolic compounds characterized by a three-ring structure and multiple hydroxyl groups. It occurs in small amounts in strawberries, apples, persimmons, grapes, onions, and some other fruits and vegetables. Its chemical name is 3,3′,4′,7-tetrahydroxyflavone, and its molecular formula is C15H10O6. Fisetin is investigated as a research compound because it can interact with redox-sensitive signaling, inflammatory transcription factors, protein kinases, and pathways that regulate cell survival and programmed cell death.
In longevity research, fisetin is best known as a candidate senotherapeutic or senolytic compound. Senescent cells are metabolically active cells that have undergone a durable cell-cycle arrest and may secrete inflammatory mediators collectively described as the senescence-associated secretory phenotype, or SASP. Cell-culture and animal studies suggest that fisetin can reduce selected senescent-cell populations and improve some age-associated phenotypes in experimental models. These findings do not establish that oral fisetin extends human lifespan, reverses aging, or safely clears senescent cells in people. Human pharmacokinetic, dose-finding, and controlled efficacy data remain comparatively limited.
Quick Reference
Member reference tables summarize the compound's research parameters.
Cell and animal studies identify fisetin as a flavonoid capable of preferentially reducing markers and burden of some senescent cell populations.
Intermittent dosing research
Mouse senotherapeutic experiments generally used intermittent rather than continuous administration; whether this translates to humans remains unestablished.
Cellular Stress & Inflammation
Supported Research
Antioxidant-response signaling
Experimental work suggests effects on oxidative-stress pathways and stress-responsive transcriptional signaling, although bioavailability limits direct extrapolation.
Inflammatory pathway modulation
In vitro and animal studies report modulation of inflammatory mediators; clinical effects in generally healthy adults are not yet established.
Healthspan & Age-Related Outcomes
Preliminary Data
Mouse healthspan findings
Late-life fisetin treatment improved selected health and lifespan measures in mouse models; these findings cannot demonstrate human longevity benefit.
Human clinical investigation
Human studies remain limited and are primarily exploratory. No fisetin regimen is proven to prevent aging or age-related disease.
Research Protocols
As reported in cited literature and research-community logs (see Research Citations below), not a personal dosing recommendation.
This member section describes parameters reported in the research literature.
Included for harm-reduction awareness only, in the event this compound is encountered outside its labeled research use. Inclusion here does not imply RUO Codes endorses, recommends, or instructs human use.
This member section discusses research safety considerations and uncertainties.
The described verification process includes looking for a lot-matched COA identifying fisetin, assay result, batch number, test date, and laboratory method.
Verified Marker
Independent identity and purity testing
Prefer products with third-party HPLC or UHPLC testing that documents identity and a stated fisetin purity, rather than an unlabeled botanical blend.
Verified Marker
Contaminant screening
A quality report should include heavy-metal and microbiological testing, with results and specification limits available for the finished product.
Acceptable Range
Clear capsule and dose disclosure
The label should state milligrams of fisetin per capsule and serving, excipients, capsule material, suggested storage, and a traceable lot number.
Quality Concern
Unverifiable potency or proprietary blends
Avoid products lacking a COA, using only generic “polyphenol complex” claims, or making implausible purity and anti-aging claims without supporting analysis.